Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

FEBS Open Bio

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关键词: Shiga toxin;    Apoptosis;    Apoptosis inhibitory proteins;    Proteasome;    Proteasome inhibitor;   

DOI  :  10.1016/j.fob.2015.06.005

来源: publisher

【 摘 要 】

Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short‐lived anti‐apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented the reduction of anti‐apoptotic proteins, and inhibited caspase activation and apoptosis, suggesting that the reduction of anti‐apoptotic proteins is a prerequisite for Stx‐induced apoptosis. A clinically approved proteasome inhibitor, bortezomib, prolonged the survival of mice challenged by Stx. These results imply that proteasome inhibition may be a novel approach to prevent the fatal effects of Stx.

【 授权许可】

Unknown