Affinity and avidity models in autoimmune disease

AIMS Allergy and Immunology

James Peterson^1¹ 

[1] Department of Mathematical Sciences, Clemson University, Clemson, SC 29634, USA^1

关键词: T cell models;    cubic ternary complex receptor;    ligand interactions;    immunological kinapses and synapses;    self versus non-self computations;    affinity;    efficacy and avidity models;   

DOI  :  10.3934/Allergy.2018.1.45

学科分类：医学（综合）

来源: American Institute of Mathematical Sciences

【 摘 要 】

In this work, we develop a theoretical model of affinity and avidity in the immune system.The model is based on an extension of the Cubic Ternary Complex (CTC) model of receptor - ligandinteractions to the immunological synapse setting. We use the resulting equation to study how lysiscan occur for a cell exhibiting only self proteins. This general affinity model gives a nice quantitativetool which can be used to explore a nonlinear model of how a T Cell can have a productive interactionwith a MHC-I complex even though the encapsulated peptide fragment is a self protein. The modelbuilt will allow the creation of even more general autoimmune models within the framework of B andT Cell differentiation via cytokine signalling families.

【 授权许可】

CC BY