AIMS Allergy and Immunology | |
Affinity and avidity models in autoimmune disease | |
James Peterson1  | |
[1] Department of Mathematical Sciences, Clemson University, Clemson, SC 29634, USA | |
关键词: T cell models; cubic ternary complex receptor; ligand interactions; immunological kinapses and synapses; self versus non-self computations; affinity; efficacy and avidity models; | |
DOI : 10.3934/Allergy.2018.1.45 | |
学科分类:医学(综合) | |
来源: American Institute of Mathematical Sciences | |
【 摘 要 】
In this work, we develop a theoretical model of affinity and avidity in the immune system.The model is based on an extension of the Cubic Ternary Complex (CTC) model of receptor - ligandinteractions to the immunological synapse setting. We use the resulting equation to study how lysiscan occur for a cell exhibiting only self proteins. This general affinity model gives a nice quantitativetool which can be used to explore a nonlinear model of how a T Cell can have a productive interactionwith a MHC-I complex even though the encapsulated peptide fragment is a self protein. The modelbuilt will allow the creation of even more general autoimmune models within the framework of B andT Cell differentiation via cytokine signalling families.
【 授权许可】
CC BY
【 预 览 】
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RO201904020409037ZK.pdf | 1152KB | download |