Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial

The British Journal of Nutrition

Panagiota Ioannidou^2¹  George V. Papatheodoridis^2²  Christina N. Katsagoni^1³ 

[1] 2nd Department of Internal Medicine,Medical School of National and Kapodistrian University of Athens,Hippokration General Hospital of Athens,114 Vassilissis Sophias Avenue,115 27 Athens,Greece^3;Department of Gastroenterology,Medical School of National and Kapodistrian University of Athens,Laiko General Hospital of Athens,17 Agiou Thoma str.,115 27 Athens,Greece^2;Department of Nutrition And Dietetics,School of Health Sciences and Education,Harokopio University,70 El. Venizelou str.,176 71 Athens,Greece^1

关键词: Non-alcoholic fatty liver disease;    Mediterranean diet;    Mediterranean lifestyle;    Weight loss;    Sleep;    Intervention;   

DOI  :  10.1017/S000711451800137X

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (sd 11) years, BMI=31·8 (sd 4·5) kg/m², 68 % men) with ultrasonography-proven NAFLD (and elevated alanine aminotransferase (ALT) and/or γ-glutamyl transpeptidase (GGT) levels) were randomised to the following groups: (A) control group (CG), (B) Mediterranean diet group (MDG) or (C) Mediterranean lifestyle group (MLG). Participants of MDG and MLG attended seven 60-min group sessions for 6 months, aiming at weight loss and increasing adherence to MD. In the MLG, additional guidance for increasing physical activity and improving sleep habits were given. Patients in CG received only written information for a healthy lifestyle. At the end of 6 months, 88·8 % of participants completed the study. On the basis of intention-to-treat analysis, both MDG and MLG showed greater weight reduction and higher adherence to MD compared with the CG (all P 0·05) at the end of intervention. In addition, MLG increased vigorous exercise compared with the other two study groups (P 0·001) and mid-day rest/naps compared with CG (P=0·04). MLG showed significant improvements in ALT levels (i.e. ALT 40 U/l (P=0·03) and 50 % reduction of ALT levels (P=0·009)) and liver stiffness (P=0·004) compared with CG after adjusting for % weight loss and baseline values. MDG improved only liver stiffness compared with CG (P 0·001) after adjusting for the aforementioned variables. Small changes towards the Mediterranean lifestyle, along with weight loss, can be a treatment option for patients with NAFLD.

【 授权许可】

CC BY