The association between white matter and sleep spindles differs in young and older individuals

Sleep

Gaudreault, Pierre-Olivier^1,2¹  Gosselin, Nadia^1,2²  Deslauriers-Gauthier, Samuel^1,3³  Lafortune, Marjolaine^1⁴ 

[1] Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, QC, Canada^1;Department of Psychology, Université de Montréal, Montreal, QC, Canada^2;Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada^4;Sherbrooke Connectivity Imaging Lab, Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada^3

关键词: aging;    diffusion tensor imaging;    EEG;    magnetic resonance imaging;    moderation analysis;    sleep spindles;    white matter integrity;   

DOI  :  10.1093/sleep/zsy113

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesSleep is a reliable indicator of cognitive health in older individuals. Sleep spindles (SS) are non-rapid eye movement (NREM) sleep oscillations implicated in sleep-dependent learning. Their generation imply a complex activation of the thalamo-cortico-thalamic loop. Since SS require neuronal synchrony, the integrity of the white matter (WM) underlying these connections is of major importance. During aging, both SS and WM undergo important changes. The goal of this study was to investigate whether WM integrity could predict the age-related reductions in SS characteristics.

【 授权许可】

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