Obstructive sleep apnea and longitudinal Alzheimer’s disease biomarker changes

Sleep

Mbah, Alfred K^1¹  Pirraglia, Elizabeth^2²  Andrade, Andreia G^2³  Bubu, Omonigho M^1,2,3,4⁴  Mukhtar, Fahad^1⁵  Sharma, Nidhi^7⁶  Sharma, Ram A^2⁷  Hogan, Megan M^3⁸  Shim, Amanda M^3⁹  Gimenez-Badia, Sandra^5^1,10  Zizi, Ferdinand^4^1,11  Seixas, Azizi A^4^1,12  Kam, Korey^8^1,13  Umasabor-Bubu, Ogie Q^6^1,14 

[1] Byrd Alzheimer’s Disease Institute, College of Medicine, Psychiatry and Behavioral Neurosciences, University of South Florida Health, Tampa, FL^11;Center for Brain Health, Department of Psychiatry, NYU Langone Medical Center, New York, NY^2;Department of Applied Health Sciences, Wheaton College, Wheaton, IL^3;Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL^1;Department of Family Medicine and Public Health, University of California—San Diego, San Diego, CA^9;Department of Molecular Science and Translational Medicine, Michigan State University, Grand Rapids, MI^10;Department of Population Health, New York University School of Medicine, Center for Healthful Behavior Change, New York, NY^4;Dipartmento Di Scienze Biochimica A. Rossi Fanelli, University of Rome, Rome, Italy^7;Division of Pulmonary, Critical Care and Sleep Medicine at the Icahn School of Medicine at Mount Sinai, New York, NY^8;Multidisciplinary Sleep Unit - Respiratory Department, Hospital de la Santa Creu i Sant Pau. IIB Sant Pau Department of Clinical Psychobiology, University of Barcelona, Barcelona, Spain^5;Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY^14;Sleep Disorders Centre, Guy’s Hospital, Great Maze Pond, London, UK^12;Sleep and Brain Plasticity Centre, Department of Neuroimaging, IoPPN, King’s College London, London, UK^13;State University New York (SUNY) Downstate Medical Center, Brooklyn, NY^6

关键词: obstructive sleep apnea;    Alzheimer’s disease;    longitudinal study;    CSF biomarkers;    brain amyloid PET;    Aβ42;    T-tau;    P-tau;   

DOI  :  10.1093/sleep/zsz048

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesTo determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) elderly.

【 授权许可】

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