Protein arginine methyltransferase 5 promotes bladder cancer growth through inhibiting NF-kB dependent apoptosis

EXCLI Journal

Xiu Wang¹  Yi Han²  Ping Wang³  Guodong Hu⁴ 

[1] Department of Urology, Shenyang Red Cross Hospital, Shenyang, Liaoning, China;Department of Anesthesia, the Affiliated Fourth Hospital of China Medical University, Shenyang, Liaoning, China;Department of Urology, Shenyang Red Cross Hospital, Shenyang, Liaoning, China;Department of Urology, the Affiliated Fourth Hospital of China Medical University, Shenyang, Liaoning, China

关键词: PRMT5;    bladder cancer;    NF-kB;    apoptosis;   

DOI  :  10.17179/excli2018-1719

学科分类：过敏症与临床免疫学

来源: University of Mainz, University of Leipzig

【 摘 要 】

Protein arginine methyltransferase 5 (PRMT5) has emerged as a key regulator of tumorigenesis. However, how PRMT5 functions in bladder cancer, the most common malignancy of the urological system, is unknown. We described here that PRMT5 is highly expressed in bladder cancer cell lines and primary human bladder cancer tissues. PRMT5 enhances the proliferation and colony formation of bladder cancer cells. PRMT5 knockdown induces bladder cancer cell apoptosis. Mechanistically, PRMT5 enhances NF-kB activation by targeting crucial anti-apoptotic genes such as BCLXL and c-IAP1, thereby inhibiting tumor cell apoptosis and sustaining proliferation. Importantly, PRMT5 inhibitor opposed tumor growth and BCLXL and c-IAP1 transcription in the bladder cancer xenograft model. Collectively, the current suggests the crucial role of PRMT5 as a promising therapeutic target in bladder cancers.

【 授权许可】

CC BY