α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder

Sleep

Martí, Carles^3¹  Vilaseca, Isabel^2²  Serradell, Mónica^1³  Iranzo, Alex^1⁴  Borrego, Sergi^1⁵ 

[1] Institute of Neurology, Medical University of Vienna, Vienna, Austria^4;Maxillofacial Surgery Service Hospital Clínic de Barcelona, Barcelona, Spain^3;Neurological Tissue Bank, Biobanc-Hospital Clinic, IDIBAPS, Barcelona, Spain^5;Neurology Service, Hospital Clínic de Barcelona, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain^1;Otorhinolaryngology Service, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Respiratorias, Bunyola, Spain^2

关键词: α-synuclein;    idiopathic rapid eye movement sleep behavior disorder;    labial minor salivary glands;    Parkinson’s disease;    dementia with Lewy bodies;   

DOI  :  10.1093/sleep/zsy101

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesTo assess whether biopsy of the labial minor salivary glands safely detects phosphorylated α-synuclein (pAS) deposits in idiopathic rapid eye movement sleep behavior disorder (IRBD), a condition that precedes the cardinal manifestations of synuclein disorders associated with Lewy-type pathology, namely, Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).

【 授权许可】

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