Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea

Sleep

Terrill, Philip I^3¹  de Melo, Camila M^1²  Taranto Montemurro, Luigi^1³  Sands, Scott A^1,2⁴  Marques, Melania^1,6⁵  Edwards, Bradley A^1,4,5⁶  Azarbarzin, Ali^1⁷ 

[1] Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School, The Alfred and Monash University, Melbourne, Victoria, Australia^2;Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA^7;Department of Physiology, Sleep and Circadian Medicine Laboratory, Monash University, Melbourne, Victoria, Australia^4;Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA^1;Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil^6;School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, Australia^3;School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia^5

关键词: arousability;    pathophysiology;    personalized medicine;    endotype;   

DOI  :  10.1093/sleep/zsx183

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesPrecision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient’s pathophysiological “traits.” Here, we provide the first automated technique to quantify the respiratory arousal threshold—defined as the level of ventilatory drive triggering arousal from sleep—using diagnostic polysomnographic signals in patients with OSA.

【 授权许可】

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