When the Locus Coeruleus Speaks Up in Sleep: Recent Insights, Emerging Perspectives

International Journal of Molecular Sciences

Laura M. J. Fernandez¹  Najma Cherrad¹  Lila Banterle¹  Anita Lüthi¹  Alejandro Osorio-Forero¹ 

[1] Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, Switzerland;

关键词: NREM sleep;    REM sleep;    monoamine;    noradrenaline;    arousability;    sleep architecture;   

DOI  :  10.3390/ijms23095028

来源: DOAJ

【 摘 要 】

For decades, numerous seminal studies have built our understanding of the locus coeruleus (LC), the vertebrate brain’s principal noradrenergic system. Containing a numerically small but broadly efferent cell population, the LC provides brain-wide noradrenergic modulation that optimizes network function in the context of attentive and flexible interaction with the sensory environment. This review turns attention to the LC’s roles during sleep. We show that these roles go beyond down-scaled versions of the ones in wakefulness. Novel dynamic assessments of noradrenaline signaling and LC activity uncover a rich diversity of activity patterns that establish the LC as an integral portion of sleep regulation and function. The LC could be involved in beneficial functions for the sleeping brain, and even minute alterations in its functionality may prove quintessential in sleep disorders.

【 授权许可】

Unknown