One Hundred Years of Linkage Disequilibrium

Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation

John A. Sved^1¹  William G. Hill^2² 

[1] Evolution and Ecology Research Centre, University of New South Wales, Sydney, 2052, Australia^1;Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom^2

关键词: LD;    recombination;    population size;    genetic drift;    GWAS;    genomic prediction;   

DOI  :  10.1534/genetics.118.300642

学科分类：医学（综合）

来源: Genetics Society of America

【 摘 要 】

One hundred years ago, the first population genetic calculations were made for two loci. They indicated that populations should settle down to a state where the frequency of an allele at one locus is independent of the frequency of an allele at a second locus, even if these loci are linked. Fifty years later it was realized what is obvious in retrospect, that these calculations ignored the effect of chance segregation of linked loci, an effect now widely recognized following the association of closely linked markers (SNPs) with rare genetic diseases. Linkage disequilibrium is now accepted as the norm for closely linked loci, leading to powerful applications in the mapping of disease alleles and quantitative trait loci, in the detection of sites of selection in the human genome, in the application of genomic prediction of quantitative traits in animal and plant breeding, in the estimation of population size, and in the dating of population divergence.

【 授权许可】

CC BY