Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives

Sleep

Thorsby, Per M^7¹  Dietrichs, Espen^6²  Andreassen, Ole A^3,4³  Westlye, Lars T^4,8⁴  Juvodden, Hilde T^1,2⁵  Alnæs, Dag^3⁶  Lund, Martina J^3,4⁷  Agartz, Ingrid^4,5⁸ 

[1] Department of Medical Biochemistry, Hormone Laboratory, Oslo University Hospital, Aker, Norway^7;Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway^6;Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway^5;Department of Psychology, University of Oslo, Oslo, Norway^8;Department of Rare Disorders, Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias (NevSom), Oslo University Hospital, Ullevål, Norway^1;Institute of Clinical Medicine, University of Oslo, Oslo, Norway^2;NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway^3;NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway^4

关键词: narcolepsy;    hypocretin;    HLA;    H1N1 vaccination;    diffusion tensor imaging;   

DOI  :  10.1093/sleep/zsy145

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesTo assess white matter involvement in H1N1-vaccinated hypocretin deficient patients with narcolepsy type 1 (NT1) compared with first-degree relatives (a potential risk group) and healthy controls.

【 授权许可】

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