Analysis of chloramphenicol in drinking water using an evaporation preparative step and isotope dilution liquid chromatography–tandem mass spectrometry

Acta Chromatographicae

Li Yonggang¹  Liu Xiaohong² 

[1] Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Centre for Disease Control and Prevention, Wuhan, 430079;Shannan region Centre for Disease Control and Prevention, Shannan region of Tibet, 856000

关键词: UHPLC–MS/MS;    chloramphenicol;    evaporation;    isotope dilution;    drinking water;   

DOI  :  10.1556/1326.2017.28404

学科分类：化学（综合）

来源: Akademiai Kiado Rt.

【 摘 要 】

A reliable isotope dilution method for the determination of chloramphenicol (CAP) in drinking water was developed by using an evaporation preparative step. Each sample was monitored by ultrahigh-pressure liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS/MS) using an electrospray ionization interface (ESI) in negative ion modes. Recoveries of spiked samples were in the range from 93.2% to 95.7% with intra-day relative standard deviation lower than 6.7% and inter-day relative standard deviation lower than 8.2%. Limit of quantification (LOD) was 0.002 ng/mL. The developed method was successfully applied to the analysis of CAP in drinking water of Shannan region of Tibet.

【 授权许可】

Unknown