In-field assessment of sodium oxybate effect in pediatric type 1 narcolepsy: an actigraphic study

Sleep

Filardi, Marco^1¹  Antelmi, Elena^1,2²  Ferri, Raffaele^3³  Pizza, Fabio^1,2⁴ 

[1] Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy^1;Department of Neurology I.C., Sleep Research Centre, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy^3;Department of Psychology, University of Bologna, Bologna, Italy^4;IRCCS, Istituto delle Scienze Neurologiche, AUSL di Bologna, Bologna, Italy^2

关键词: type 1 narcolepsy;    children;    actigraphy;    sodium oxybate;    cataplexy;    weight loss;   

DOI  :  10.1093/sleep/zsy050

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesSodium oxybate (SXB) is a GABAergic agent widely used as off-label treatment in pediatric type 1 narcolepsy (NT1). Here, we aimed at analyzing by wrist actigraphy the sleep/wake profile of NT1 children and adolescents in drug-naïve condition and after 1 year of SXB treatment. As secondary aim, we investigated changes on sleepiness, cataplexy, and children’s anthropometric profile after 1 year of SXB treatment.

【 授权许可】

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