Edema from Taking Cinnamon for Treatment of Diabetes: Similar Biochemistry and Pathophysiology to Thiazolidinedione Medications

Journal of the American Board of Family Medicine: JABFM

Paul Crawford^1¹ 

[1] From the Nellis Family Medicine Residency, Nellis AFB, NV^1

关键词: Cinnamon;    Edema;    Heart Failure;    Peroxisome Proliferator-Activated Receptors;    Thiazolidinediones;   

DOI  :  10.3122/jabfm.2018.05.180024

学科分类：过敏症与临床免疫学

来源: The American Board of Family Medicine

【 摘 要 】

We present a report of cinnamon bark powder 1000 mg daily associated with edema that resolved after stopping the supplement in an adult male. Thiazolidinediones (TZDs) cause fluid retention in those with diabetes or prediabetes. Some medications in this class have been implicated in increased cardiac deaths from this side effect. While medications are effective for diabetes, many people have turned to natural remedies to treat their diabetes instead of conventional pharmaceuticals. Cinnamon is a common agent used, and it has received extensive lay press attention. Chemically, cinnamon bark powder activates peroxisome proliferated activated receptors similar to TZDs. It is reasonable to hypothesize that cinnamon bark powder can cause edema. This case demonstrates that cinnamon bark powder may have a similar side effect profile. Physicians should be aware that consumption of cinnamon bark powder could cause fluid retention and possibly worsen congestive heart failure.

【 授权许可】

CC BY