Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

eXPRESS Polymer Letters

J. Odrobinska¹ 

关键词: tailor-made polymers;    nanomaterials;    bioinitiator;    antioxidants;    delivery systems;   

DOI  :  10.3144/expresspolymlett.2019.69

学科分类：生物科学（综合）

来源: eXPRESS Polymer Letters

【 摘 要 】

Amphiphilic copolymers containing 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA)units were synthesized by controlled atom transfer radical polymerization (ATRP) applying bromoester modified retinol(RETBr) as a novel initiator. Analogous series of copolymers with adjustable hydrophilic-hydrophobic balance was obtainedwith the use of a standard initiator, i.e. ethyl α-bromoisobutyrate (EBriB). The self-assembling particles, prepared by thesolvent evaporation, were loaded with vitamin C (VitC) or ferulic acid (FA). The hydrophilic/hydrophobic ratio in the copolymerwas indicated as a crucial factor to regulate efficiencies of encapsulation processes in the range of 53–98%. In vitro releaseof bioactive substance was carried out in phosphate buffer solution (PBS) at pH 7.4 with the maximum amount ofVitC after 1h (27–62%) or FA within 2 h (71–97%). The polymeric systems with satisfactory encapsulation characteristicsand release profiles are attractive micellar carriers of antioxidants, which, due to their activities could be also delivered usingthe popular approaches in cosmetology like masks, under-eye patches, or wraps.

【 授权许可】

CC BY