The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation

Sleep

Matsumoto, Riki^2¹  Yoshida, Kazumichi^7²  Usami, Kiyohide^1,2³  Korzeniewska, Anna^1⁴  Mikuni, Nobuhiro^7,9⁵  Kunieda, Takeharu^7,8⁶  Kikuchi, Takayuki^7⁷  Kobayashi, Katsuya^2⁸  Matsuhashi, Masao^5,6⁹  Hitomi, Takefumi^3,4^1,10 

[1] Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^3;Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^10;Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD^1;Department of Neurology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^2;Department of Neurosurgery, Ehime University Graduate School of Medicine, Shizukawa Toon city, Ehime, Japan^8;Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^7;Department of Neurosurgery, Sapporo Medical University, Chuo-ku, Sapporo, Japan^9;Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^4;Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan^6;Research and Educational Unit of Leaders for Integrated Medical System, Kyoto University Graduate School of medicine, Sakyo-ku, Kyoto, Japan^5

关键词: brain waves;    human electrocorticography;    high-gamma activity;    effective connectivity;    causal interactions;   

DOI  :  10.1093/sleep/zsz050

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing versus planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80–150 Hz), which indexes changes in neuronal population firing rates. Using event-related causality (ERC) analysis, we found that the overall patterns of neural propagation among sites with CCSRHG were different during wakefulness and different sleep stages. For example, stimulation of frontal lobe elicited greater propagation toward parietal lobe during slow-wave sleep than during wakefulness. During REM sleep, we observed a decrease in propagation within frontal lobe, and an increase in propagation within parietal lobe, elicited by frontal and parietal stimulation, respectively. These biases in the directionality of large-scale cortical network dynamics during REM sleep could potentially account for some of the unique experiential aspects of this sleep stage. Together these findings suggest that the regulation of conscious awareness and sleep is associated with differences in the balance of neural propagation across large-scale frontal-parietal networks.

【 授权许可】

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