15d-PGJ2 is a new hope for controlling tumor growth

American Journal of Translational Research

Haixin Dong¹  Qingli Bie²  Chengqiang Jin³ 

[1] Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, Shandong, P. R. China;Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, P. R. China;Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, P. R. China

关键词: Prostaglandins;    15d-PGJ2;    apoptosis;    anti-inflammatory;    angiogenesis;    metastasis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a natural PPARγ agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.

【 授权许可】

CC BY-NC