Zataria multiflora Alleviates Cisplatin-Induced Oxidative Stress, Apoptosis, and Nephrotoxicity in Mice

Jundishapur Journal of Natural Pharmaceutical Products

Shokooh Karimi¹  Seyed Jalal Hosseinimehr²  Ali Reza Khalatbary³  Hamid Reza Mohammadi⁴  Fereshteh Talebpour Amiri⁵ 

[1] Department of Anatomy, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;Pharmacutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran;Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

关键词: <;    i>;    Zataria multiflora<;    /i>;    Alleviates Cisplatin-Induced Oxidative Stress;    Apoptosis;    and Nephrotoxicity in Mice;    Cisplatin;    Zataria multiflora Boiss;    Nephrotoxicity;    Caspase-3;    articles;    63293;   

DOI  :  10.5812/jjnpp.63293

学科分类：药理学

来源: Jundishapur Journal of Natural Pharmaceutical Products

【 摘 要 】

Cisplatin (CP), as an anticancer drug, causes nephrotoxicity. Zataria multiflora Boiss (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties.The current study investigated the effects of ZM on cisplatin-induced nephrotoxicity.In the current experimental study, 22 male mice were randomly divided into four groups: the control; the ZM, 200 mg/kg during seven days via gavage; the CP, 10 mg/kg intraperitoneally on the 5th day of study; and the ZM + CP. Serum creatinine and urea levels, malondialdehyde (MDA), glutathione (GSH) and protein carbonyl (PC) levels in renal tissue of mice were histopathologically and immunohistochemically assessed to determine nephrotoxicity.CP caused a significant increase in serum creatinine and urea levels, increased oxidative stress in kidney tissue, caused histological changes, and increased caspase-3 immunoreactivity. ZM significantly mitigated the toxic effects of CP on the kidney tissue. In addition, treatment with ZM significantly reduced immunoreactivity of caspase-3.The findings of the present study suggested that the ZM as a potential antioxidant compound with scavenging free radicals and anti-apoptosis property attenuated the nephrotoxicity induced by cisplatin.

【 授权许可】

CC BY-NC