Antiproliferative Effects of a Series of Pyrazolines on Lung Cancer

Proceedings

Tilki, Elif Kaya¹  Sever, Belgin²  Altıntop, Mehlika Dilek³  Dikmen, Miriş⁴ 

[1] Author to whom correspondence should be addressed.;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey;Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey;Presented at the 2nd International Cell Death Research Congress, Ä°zmir, Turkey, 1–4 of November 2018

关键词: lung cancer;    antiproliferative activity;    pyrazoline;   

DOI  :  10.3390/proceedings2251574

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Lung cancer is one of the most diagnosed cancers worldwide and the development of anticancer agents for the treatment of lung cancer is an important task for researchers. For this purpose, herein pyrazoline-based compounds 1–18 were investigated for their cytotoxic effects on A549 human lung adenocarcinoma and CCD-19Lu human lung fibroblast cell lines using MTT assay. According to the results, 1-(4-methoxyphenyl)-3-(2-furanyl)-5-(4-methylphenyl)-2-pyrazoline (7) was identified as the most promising anticancer agent due to its selective inhibitory effect on A549 cell line with an IC50 value of 138.63 µg/mL when compared with cyclophosphamide (IC50 = 309.97 µg/mL).

【 授权许可】

CC BY