LncRNA MALAT1 promotes relapse of breast cancer patients with postoperative fever

American Journal of Translational Research

Yong Liu¹  Zhihua Li²  Liang Xu³  Shaokun Fu⁴ 

[1] Clinical Laboratory, The Third Hospital of Nanchang City, Nanchang 330009, Jiangxi, Peoples Republic of China;Department of Breast Surgery, The Third Hospital of Nanchang City, Nanchang 330009, Jiangxi, Peoples Republic of China;Key Laboratory of Breast Diseases in Jiangxi Province, Nanchang 330009, Jiangxi, Peoples Republic of China;Pathology Department, The Third Hospital of Nanchang City, Jiangxi Breast Specialist Hospital, Nanchang 330009, Jiangxi, Peoples Republic of China

关键词: MALAT1;    breast cancer;    postoperative fever;    recurrence;    metastasis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Postoperative fever is prevalent in many breast cancer patients. Some retrospective studies proposed that postoperative fever might also be considered as a rapid rough indicator for the poor prognosis of breast cancer patients. This study aims to explore the possible molecular mechanisms underlying the relapse of breast cancer patients with early postoperative fever. Our results indicated plasma levels of lncRNA MALAT1 were elevated in breast cancer patients with early postoperative fever and were associated with RFS. Lipopolysaccharide (LPS) was able to induce fever and systemic inflammatory responses in 4T1 xenograft mice, and promote lung metastasis. But after knocking down lncRNA MALAT1, the inflammatory responses and metastasis of lung were significantly reduced. Moreover, after knocking down lncRNA MALAT1 in the 4T1 cells, TNF-α level in the supernatants was sharply decreased, and the invasion and migration induced by LPS was also weakened. Cumulatively, our data indicates that MALAT1 is closely related to recurrence and metastasis of breast cancer patients with early postoperative fever.

【 授权许可】

CC BY-NC