High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer

Pathology oncology research: POR

Joanna Harasym¹  Anna Choromanska²  Julita Kulbacka³ 

[1] University of Wroclaw;Wroclaw Medical University;Wroclaw University of Economics

关键词: Oat beta-glucan;    Viability;    Lung cancer;    Keratinocytes;    Oxidative stress;    Cytoskeleton;   

DOI  :  10.1007/s12253-017-0278-3

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation. Additionally the level of red blood cells hemolysis was performed. Our results indicate strong anti-tumor properties of new beta-glucan from oat and at the same time no toxicity for normal cells.

【 授权许可】

CC BY