Genotipificación del Virus de Papiloma Humano en mujeres de la comuna norte de Bucaramanga

Universidad Industrial de Santander. Revista. Salud

Rincón-Orozco, Bladimiro¹  Torrado G, Laura M² 

[1] Universidad Industrial de Santander, Colombia;Universidad de Santander, Colombia

关键词: Uterine cervical neoplasms;    molecular diagnostic techniques;    Human Papillomavirus DNA Tests;    early detection of cancer;    cross sectional analysis.;   

DOI  :  10.18273/revsal.v50n3-2018007

学科分类：医学（综合）

来源: Universidad Industrial de Santander

【 摘 要 】

Introduction: Persistent infection with high-risk Human Papilloma Virus is a necessary cause for the appearance of cervical cancer.Objective: Molecularly characterize circulating genotypes of Human Papilloma Virus in population of the north of Bucaramanga.Methods: Cross-sectional study in women aged from 35 to 65 years with risk ≥3 points for develop cervical cancer determined by a standardized survey. In a cervico-vaginal self-sampling probe a molecular test was performed by HPV Direct Flow CHIP technology.Results: 810 women were interviewed, of these 435 (53.7%) performed self-sampling due to the risk calculated. The median age was 47.3 years (RIQ 41-53 years). Almost the entire population resides in poor conditions (stratum1 and 2) (98.8%) and most of them are from the Colombian subsidized social security system (87.2%). The prevalence was 10.6% (CI 95%: 7.8 - 13.8), for high risk genotypes it was 3.9% (CI 95%: 2.3 - 6.2), low risk of 3.5% (CI 95%: 1.4 - 5.6) and for indeterminate genotype of 1.9%. HPV-59 was the most common high-risk genotype and HPV-62/81 was a low-risk genotype. There was coinfection with high risk / low risk genotypes in five women and coinfection with two low risk genotypes in a woman.Conclusion: The prevalence of infection by Human Papilloma Virus in women living in vulnerable areas of Bucaramanga is lower than that reported in Bogotá and Cali (14.9% and 13%, respectively). No predominance of any particular high-risk genotype was found.

【 授权许可】

Unknown