Current oncology | |
Anti-Yo antibody–mediated paraneoplastic cerebellar degeneration associated with cognitive affective syndrome in a patient with breast cancer: a case report and literature review | |
M. Le May1  | |
[1] University of Ottawa | |
关键词: Paraneoplastic syndrome; her2; anti-Yo antibody; breast cancer; cerebellar degeneration; cognitive affective syndrome; | |
DOI : 10.3747/co.25.4106 | |
学科分类:肿瘤学 | |
来源: Multimed, Inc. | |
【 摘 要 】
Breast cancer is the most common cancer in women, with 15%–25% of those tumours overexpressing the human epidermal growth factor receptor 2 (her2), which is associated with more aggressive disease. On rare occasions, patients present with a paraneoplastic syndrome months to years before their cancer diagnosis. Paraneoplastic cerebellar degeneration (pcd) is associated with fewer than 1% of cancers and is strongly associated with breast and gynecologic malignancies. Anti-Yo antibody is the antibody most frequently identified with the syndrome, and it is associated with a very poor prognosis. Recent studies have implicated a relationship between overexpression of her2 and anti-Yo–mediated pcd. Current pcd treatments include tumour removal, chemotherapy, targeted therapy, and immune-suppressive treatments. Outcomes of pcd are typically poor, and no guidelines for treatment currently exist. Early recognition followed by rapid initiation of treatment remains the cornerstone of therapy.Here, we present a case of anti-Yo-antibody pcd secondary to estrogen and progesterone receptor–negative, her2-positive breast cancer. Despite treatment with mastectomy, chemotherapy, and her2-targeted therapy, no significant neurologic improvement was achieved, and cerebellar cognitive affective syndrome subsequently developed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201910257584154ZK.pdf | 177KB | download |