How does Toxoplama gondii invade host cells?

The Journal of Veterinary Medical Science

Kentaro KATO¹ 

[1] National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan

关键词: glideosome;    host adhesion receptor;    invasion;    moving junction;    Toxoplasma gondii;   

DOI  :  10.1292/jvms.18-0344

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Toxoplasma gondii is a highly prevalent protozoon that can infect all warm-blooded animals, including humans. It is frequently used as an Apicomplexan parasite model in research. In this review, the invasion mechanism of T. gondii is described as a representative Apicomplexan parasite. The invasion machinery of T. gondii consists of the moving junction and the glideosome, which is a specific motor system for Apicomplexan parasites. I provide details about the moving junction, parasite-secreted proteins and host adhesion receptors, the glideosome, and calcium signaling, which generates the power for the gliding mobility of T. gondii. A detailed understanding of parasite invasion can be useful for the development of new effective drugs to inhibit this event and disrupt the Apicomplexan life cycle.

【 授权许可】

Unknown