Factors associated with adherence and persistence to hormonal therapy in women with breast cancer

Revista Brasileira de Epidemiologia

Guedes, Juliana Barroso Rodrigues¹  Alvim, Mariana Macedo²  Guerra, Maximiliano Ribeiro³ 

[1] Centro Universitário Unifaminas, Muriaé, Brasil;PSL Research University, Paris, France;Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil

关键词: Breast neoplasms;    Antineoplastic agents;    Hormonal;    Medication adherence;    Patient dropouts;    Risk factors;    Drug therapy.;   

DOI  :  10.1590/1980-5497201700040007

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

Introduction:Hormonal therapy in breast cancer is essential to the transition from active treatment to care survival, because it improves long-term survival and provides a better quality of life. reducing hospital costs as well. However, adherence and persistence in the recommended treatment are important to achieve the desirable results.Methodology:This is a cohort retrospective study of 182 women on hormonal treatment identified at a high complexity oncology unit, in the southeastern region of Brazil, and followed-up until 2014. We performed a bivariate analysis to analyze the factors associated with adherence and we conducted the multivariate Cox regression to identify variables associated with discontinuity of treatment over time.Results:Overall adherence was 85.2% and persistence was 45.4% at the end of 5 years. No association was found between the studied independent variables and adherence. Women with advanced stage (HR = 2.24; 95% confidence interval 1.45 - 3.45), who did not undergo surgery (HR = 3.46; 95%CI 2.00 - 5.97), and with three or more hospitalizations (HR = 6.06; 95%CI 2.53 - 14.54) exhibited increased risk of discontinuity.Discussion:The variables associated with persistence reflect the relation between the highest disease severity and the discontinuity of adjuvant hormonal treatment.Conclusion:Despite the high adherence level, there is a progressive increase in non-persistence among women on hormonal therapy, influenced by characteristics related to disease severity, which contributes to an inadequate therapeutic response.

【 授权许可】

CC BY