Biopharmaceuticals from microorganisms: from production to purification

Revista de microbiologia

Cardoso, Samuel Leite¹  Feitosa, Valker de Araújo²  Breyer, Carlos Alexandre³  Geraldes, Danilo Costa⁴  Jozala, Angela Faustino⁵  Tundisi, Louise Lacalendola⁶ 

[1]Universidade Estadual de Campinas, Campinas, Brazil

[2]Universidade Estadual de São Paulo, Brazil

[3]Universidade de Brasília, Brasília, Brazil

[4]Universidade de Campinas, Campinas, Brazil

[5]Universidade de Sorocaba, Sorocaba, Brazil

[6]Universidade de São Paulo, São Paulo, Brazil

关键词: Biopharmaceuticals;    Fermentation process;    Biotechnology;    Upstream process;    Downstream process.;   

DOI  :  10.1016/j.bjm.2016.10.007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Microbiologia / Brazilian Society for Microbiology

【 摘 要 】

The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.

【 授权许可】

CC BY-NC