Crystal structures of two 1,3-thia­zolidin-4-one derivatives featuring sulfide and sulfone functional groups

Acta Crystallographica Section E: Crystallographic Communications

Yennawar, H.P.¹  Gandla, D.²  Cannon, K.³  Silverberg, L.J.⁴ 

[1] Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA;Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania, 19122, USA;Department of Chemistry, The Pennsylvania State University, Abington College, 1600 Woodland Road, Abington, Pennsylvania, 19001, USA;Department of Chemistry, The Pennsylvania State University, Schuylkill Campus, 200 University Drive, Schuylkill Haven, Pennsylvania, 17972, USA

关键词: CRYSTAL STRUCTURE;    THIAZOLIDIN-4-ONE;    THIAZOLIDINONE;    ENVELOPE PUCKER;    CHAIR CONFORMATION;   

DOI  :  10.1107/S2056989018015098

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The crystal structures of two closely related compounds, 1-cyclo­hexyl-2-(2-nitro­phen­yl)-1,3-thia­zolidin-4-one, C15H18N2O3S, (1) and 1-cyclo­hexyl-2-(2-nitro­phen­yl)-1,3-thia­zolidin-4-one 1,1-dioxide, C15H18N2O5S, (2), are presented. These compounds are comprised of three types of rings: thia­zolidinone, nitrophenyl and cyclo­hexyl. In both structures, the rings are close to mutually perpendicular, with inter­planar dihedral angles greater than 80° in each case. The thia­zol­idinone rings in both structures exhibit envelope puckering with the S atom as flap and the cyclo­hexyl rings are in their expected chair conformations. The two structures superpose fairly well, except for the orientation of the nitro groups with respect to their host phenyl ring, with a difference of about 10° between 1 and 2. The extended structure of 1 has two kinds of weak C—H⋯O inter­actions, giving rise to a closed ring formation involving three symmetry-related mol­ecules. Structure 2 has four C—H⋯O inter­actions, two of which are exclusively between symmetry-related thia­zolidinone dioxide moieties and have a parallel `give-and-take-fashion' counterpart. In the other two inter­actions, the nitrophenyl ring and the cyclo­hexane ring each offer an H atom to the two O atoms on the sulfone group. Additionally, a C—H⋯π inter­action between a C—H group of the cyclo­hexane ring and the nitrophenyl ring of an adjacent mol­ecule helps to consolidate the structure.

【 授权许可】

CC BY