Alterations of fecal bacterial communities in patients with lung cancer

American Journal of Translational Research

Xiao-Peng Dong¹  Jun-Wen Luo²  Ying-Tao Hao³  Wei-Quan Zhang⁴  Shu-Kang Zhao⁵ 

[1] Cancer Center, The Second Hospital of Shandong University, Shandong, P. R. China;Department of Pathology, The Second Hospital of Shandong University, Shandong, P. R. China;Department of Thoracic Surgery, Shandong Provincial Chest Hospital, Jinan 250000, Shandong, P. R. China;Department of Thoracic Surgery, The Second Hospital of Shandong University, Shandong, P. R. China;School of Medicine, Shandong University, Jinan 250000, Shandong, P. R. China

关键词: Lung cancer;    gut bacteria;    carcinogenesis;    microbial dysbiosis;    16S rRNA gene sequencing;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Emerging evidence suggests the microbiome may affect a number of diseases, including lung cancer. However, the direct relationship between gut bacteria and lung cancer remains uncharacterized. In this study, we directly sequenced the hypervariable V1-V2 regions of the 16S rRNA gene in fecal samples from patients with lung cancer and healthy volunteers. Unweighted principal coordinate analysis (PCoA) revealed a clear difference in the bacterial community membership between the lung cancer group and the healthy control group. The lung cancer group had remarkably higher levels of Bacteroidetes, Fusobacteria, Cyanobacteria, Spirochaetes, and Lentisphaerae but dramatically lower levels of Firmicutes and Verrucomicrobia than the healthy control group (P < 0.05). Despite significant interindividual variation, eight predominant genera were significantly different between the two groups. The lung cancer group had higher levels of Bacteroides, Veillonella, and Fusobacterium but lower levels of Escherichia-Shigella, Kluyvera, Fecalibacterium, Enterobacter, and Dialister than the healthy control group (P < 0.05). Most notably, correlations between certain specific bacteria and serum inflammatory biomarkers were identified. Our findings demonstrated an altered bacterial community in patients with lung cancer, providing a significant step in understanding the relationship between gut bacteria and lung cancer. To our knowledge, this is the first study to evaluate the correlations between certain specific bacteria and inflammatory indicators. To better understand this relationship, further studies should investigate the underlying mechanisms of gut bacteria in lung cancer animal models.

【 授权许可】

CC BY-NC