Helicobacter pylori resistance to antibiotics in Primorsko-goranska county

Medicina Fluminensis

Bubonja-Å onje, Marina¹  Gregorović-Kesovija, Palmira²  Ambrožić, Damir³ 

[1] Klinički zavod za kliničku mikrobiologiju, KBC Rijeka, Rijeka;Nastavni zavod za javno zdravstvo Primorsko-goranske županije, Rijeka;Zavod za mikrobiologiju i parazitologiju, Medicinski fakultet SveučiliÅ¡ta u Rijeci, Rijeka

关键词: antibiotic resistance;    antibiotics;    Helicobacter pylori;   

DOI  :  10.21860/medflum2018_203550

学科分类：医学（综合）

来源: Medicina Fluminensis

【 摘 要 】

Aim: There is no bacterial infection with so many different therapeutic options as for infection caused by Helicobacter pylori for which an optimal therapeutic approach has not yet been found. Recommended therapeutic schemes depend on H. pylori resistance to antimicrobial drugs in a particular region, however, empirical treatment of infections along with increasing resistance to antibiotics often results in a therapeutic failure. The aim of this study was to determine the trend and the prevalence of helicobacter antibiotic resistance in Primorsko-goranska county during the five-year period. Methods: This study presents the results of H. pylori antimicrobial susceptibility testing from year 2013 to 2017. Data were obtained from the archives of the Department of Clinical Microbiology, Clinical Hospital Centre Rijeka and the Department of Microbiology, Teaching Institute of Public Health of Primorsko-Goranska County. Results: High-level resistance to clarithromycin and metronidazole was noticed. Rare resistance to levofloxacin was observed whereas resistance to rifampicin and amoxicillin was found sporadically. Resistance to tetracycline was not detected. Conclusions: The high resistance rate to metronidazole and clarithromycin as well as high dual resistance to both antibiotics observed in about a quarter clinical isolates can impair the efficacy of these antimicrobials in empirical eradication treatment. In addition, worrying appearance of multiple resistance to antibiotics in 10% of isolates was observed. Surveillance of local antimicrobial resistance is necessary in order to establish the relevant treatment guidelines.

【 授权许可】

CC BY