Upregulation of long non-coding RNA SNHG6 promote esophageal squamous cell carcinoma cell malignancy and its diagnostic value

American Journal of Translational Research

Yueli Zhang¹  Ruijia Li² 

[1] Department of Clinical Pharmacy, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, P. R. China;Department of Pharmacy, The Eight Hospital of Xian, Xian, P. R. China

关键词: Long non-coding RNAs;    SNHG6;    esophageal squamous cell carcinoma;    diagnostic;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Aim: To investigate the expression of lncRNA SNHG6 in esophageal squamous cell carcinoma (ESCC), the biological function of SNHG6 in ESCCs, and evaluate its diagnostic value in ESCC. Methods: SNHG6 expression in tissues and cells was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The effect of SNHG6 on the cell proliferation, migration and invasion was detected by CCK-8 assay and transwell assay, respectively. Results: SNHG6 expression was upregulated in ESCC tissues and ESCCs. Upregulated SNHG6 expression was correlated with prognosis, lymph node metastasis, distant metastasis and TNM stage of ESCC patients. SNHG6 promoted the abilities of cell proliferation, migration and invasion in ESCCs, knockdown of SNHG6 reversed these effects. SNHG6 might serve as an independently diagnostic biomarker for lymph node metastasis, distant metastasis and TNM stage. Conclusion: SNHG6 may exert oncogenic function in ESCC and may be a potential diagnostic marker for this cancer.

【 授权许可】

CC BY-NC