Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes

Proceedings

Radulović, Katarina¹  Jokić, Ivana²  Djurić, Zoran³  Frantlović, MiloÅ¡⁴ 

[1] Author to whom correspondence should be addressed.;ICTM—Institute of Microelectronic Technologies, University of Belgrade, 11000 Belgrade, Serbia;Institute of Technical Sciences of SASA, Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia;Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018.

关键词: microfluidic sensor;    stochastic time response;    competitive adsorption;    mass transfer;   

DOI  :  10.3390/proceedings2130991

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.

【 授权许可】

CC BY