The Journal of Veterinary Medical Science | |
Leukopenia induced by micafungin in a bottlenose dolphin (Tursiops truncatus): a case report | |
Yuichiro AKUNE1  Yoshito OHNO2  | |
[1] Cooperative Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan;Port of Nagoya Public Aquarium, 1-3 Minato-machi, Minato-ku, Nagoya, Aichi 455-0033, Japan | |
关键词: bottlenose dolphin; fungal pneumonia; G-CSF; leukopenia; micafungin; | |
DOI : 10.1292/jvms.18-0391 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
A bottlenose dolphin (Tursiops truncatus) housed in the Port of Nagoya Public Aquarium (PNPA) presented with symptomatic pneumonia caused by Aspergillus fumigatus. The dolphin was treated with micafungin. On days 2 and 11 after the first administration of micafungin, results from a physical examination and laboratory test indicated a decline of body temperature (BT) and leukopenia, with lowest BT, white blood cells (WBCs), and segmented neutrophils (SEGs) of 34.2°C, 600 cells/µl, and 67 cells/µl, respectively. BT, WBCs, and SEGs returned to normal range after administration of granulocyte colony stimulating factor (G-CSF). To the best of our knowledge, this is the first report of micafungin-induced decline of BT and leukopenia that was successfully treated with G-CSF in a bottlenose dolphin.
【 授权许可】
Unknown
【 预 览 】
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RO201910255421334ZK.pdf | 1260KB | download |