Leukopenia induced by micafungin in a bottlenose dolphin (Tursiops truncatus): a case report

The Journal of Veterinary Medical Science

Yuichiro AKUNE¹  Yoshito OHNO² 

[1] Cooperative Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan;Port of Nagoya Public Aquarium, 1-3 Minato-machi, Minato-ku, Nagoya, Aichi 455-0033, Japan

关键词: bottlenose dolphin;    fungal pneumonia;    G-CSF;    leukopenia;    micafungin;   

DOI  :  10.1292/jvms.18-0391

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A bottlenose dolphin (Tursiops truncatus) housed in the Port of Nagoya Public Aquarium (PNPA) presented with symptomatic pneumonia caused by Aspergillus fumigatus. The dolphin was treated with micafungin. On days 2 and 11 after the first administration of micafungin, results from a physical examination and laboratory test indicated a decline of body temperature (BT) and leukopenia, with lowest BT, white blood cells (WBCs), and segmented neutrophils (SEGs) of 34.2°C, 600 cells/µl, and 67 cells/µl, respectively. BT, WBCs, and SEGs returned to normal range after administration of granulocyte colony stimulating factor (G-CSF). To the best of our knowledge, this is the first report of micafungin-induced decline of BT and leukopenia that was successfully treated with G-CSF in a bottlenose dolphin.

【 授权许可】

Unknown