Endocrine journal | |
Different daily glycemic profiles after switching fromonce-daily alogliptin plus twice-daily metformin to their once-daily fixed-dose combination in Japanese type 2 diabetic patients | |
Mitsuyoshi Takahara1  Yoshifumi Maeno2  Naoto Katakami3  Toshihiko Shiraiwa4  | |
[1] Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan | |
关键词: Fixed-dose combination; Alogliptin; Once-daily metformin; Self-monitoring of blood glucose; Flash glucose monitoring; | |
DOI : 10.1507/endocrj.EJ18-0313 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
The aim of this study was to investigate whether daily glycemic profiles and treatment satisfaction would be changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily in type 2 diabetic patients. Twenty adult Japanese type 2 diabetic patients in whom once-daily 25-mg alogliptin plus twice-daily 250-mg metformin were switched to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily participated. Before and one month after the switch, participants were asked to perform one day of seven-point self-monitoring of blood glucose (SMBG), to wear a sensor of flash glucose monitoring for up to 14 days, and to respond to a questionnaire for treatment satisfaction. As a result, the SMBG profiles were significantly changed after the switch (p = 0.021); blood glucose levels 2 hours after breakfast were significantly elevated (p = 0.022), whereas those 2 hours after lunch were significantly reduced (p = 0.036). The flash glucose monitoring also demonstrated a significant change of daily glucose profiles (p < 0.001). The risk of glucose levels <80 mg/dL were decreased from evening to morning, while the risk of glucose levels ≥140 mg/dL were increased. Mean 24-hour glucose values were increased by 5 mg/dL on average (p < 0.001). Treatment satisfaction was significantly improved after the switch (p < 0.001). In conclusion, daily glycemic profiles were significantly changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the once-daily fixed-dose combination in Japanese type 2 diabetic patients. Treatment satisfaction was significantly improved after the switch.
【 授权许可】
Unknown
【 预 览 】
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RO201910255260438ZK.pdf | 1561KB | download |