Iron and magnetic: new research direction of the ferroptosis-based cancer therapy

American Journal of Cancer Research

an Dong¹  Jie Luo²  Zhihao Zhang³  Shenghang Wang⁴  D⁵ 

[1] Department of Spine Surgery, Shenzhen Peoples Hospital, Shenzhen, China;Institute for Research Development in Shenzhen, Northwestern Polytechnical University, Shenzhen 518057, China;Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xian 710072, Shaanxi, China;School of Life Sciences, Northwestern Polytechnical University, Xian 710072, Shaanxi, China;Zhejiang Heye Health Technology Co., Ltd., Anji, China

关键词: Iron metabolism;    iron-based nanoparticles;    magnetic field;    ferroptosis;    cancer therapy;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Ferroptosis is an iron depend cell death which caused by lipid peroxidation. Abnormal iron metabolism and high intracellular iron content are the characteristics of most cancer cells. Iron is a promoter of cell growth and proliferation. However, iron also could take part in Fenton reaction to produce reactive oxygen species (ROS). The intercellular ROS could induce lipid peroxidation, which is necessary for ferroptosis. Iron metabolism mainly includes three parts: iron uptake, storage and efflux. Therefore, iron metabolism-related genes could regulate intercellular iron content and status, which can be involved ferroptosis. In recent years, the application of nanoparticles in cancer therapy research has become more and more extensive. The iron-based nanoparticles (iron-based NPs) can release ferrous (Fe2+) or ferric (Fe3+) in acidic lysosomes and inducing ferroptosis. Magnetic field is widely used in the targeted concentration of iron-based NPs related disease therapy. Furthermore, multiple studies showed that magnetic fields can inhibit cancer cell proliferation by promoting intracellular ROS production. Herein, we focus on the relationship of between ferroptosis and iron metabolism in cancer cells, the application of nanoparticles and magnetic field in inducing ferroptosis of cancer cells, and trying to provide new ideas for cancer treatment research.

【 授权许可】

CC BY-NC