An overview of MCT1 and MCT4 in GBM: small molecule transporters with large implications

American Journal of Cancer Research

Simon J Park¹  Chase P Smith²  Ryan R Wilbur³  Charles P Cain⁴ 

[1] Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA;Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, USA;Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, IL, USA;Illinois Neurological Institute, Peoria, IL, USA

关键词: Monocarboxylate transporter;    MCT1;    MCT4;    glioblastoma;    cancer;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins encoded by the SLC16 gene family found ubiquitously across mammalian species. Two members of this family, MCT1 and MCT4, have been linked to key roles in the metabolic activity of tissues through the proton-coupled transport of monocarboxylates, most notably L-lactate, ketone bodies, and pyruvate. This review aims to provide an overview of MCT1 and MCT4, followed by the implications of their expression in a multitude of cancers and in glioblastoma (GBM) specifically. Further, the possible mechanisms underlying these effects will be discussed. Given the relationships between MCT1 and MCT4 and cancer, they offer a unique opportunity for novel treatment strategies. We aim to explore current therapies focused on MCT1 and MCT4 and propose future studies to better understand their role in GBM to optimize future treatment regimens.

【 授权许可】

CC BY-NC