Translational control of mRNAs by 3′-Untranslated region binding proteins

BMB Reports

Akio Yamashita^1¹  Osamu Takeuchi^2² 

[1]Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan^1

[2]Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan^2

关键词: RNA binding protein;   

DOI  :  10.5483/BMBRep.2017.50.4.040

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3′-untranslated regions (UTRs) of mRNAs. mRNA 3′-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.

【 授权许可】

Unknown