Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system

Proceedings of the Japan Academy, Series B. Physical and Biological Sciences

Masashi ITO¹  Shoji IMAMICHI²  Satoshi NAKAMURA³  Shie NISHIOKA⁴  Akihisa WAKITA⁵  Kazuyoshi MASUMOTO⁶  Hiroyuki OKAMOTO⁷ 

[1] Clinical Trial Center;Department of Physics, Rikkyo University;Department of Radiation Oncology, National Cancer Center Hospital;Department of Radiological Technology, National Cancer Center Hospital;Division of Genetics, National Cancer Center Research Institute;Division of Research and Development for boron neutron capture therapy, National Cancer Center Exploratory Oncology Research &High Energy Accelerator Research Organization (KEK)

关键词: boron neutron capture therapy (BNCT);    accelerator-based BNCT;    induced radioactivity;    radioactivation;   

DOI  :  10.2183/pjab.93.051

学科分类：物理（综合）

来源: Japan Academy

【 摘 要 】

This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron neutron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated using a high-purity germanium (HP-Ge) detector. The saturated radioactivity of the irradiated mouse was estimated to assess the radiation protection needs for using the accelerator-based BNCT system. 24Na, 38Cl, 80mBr, 82Br, 56Mn, and 42K were identified, and their saturated radioactivities were (1.4 ± 0.1) × 102, (2.2 ± 0.1) × 101, (3.4 ± 0.4) × 102, 2.8 ± 0.1, 8.0 ± 0.1, and (3.8 ± 0.1) × 101 Bq/g/mA, respectively. The 24Na activation rate at a given neutron fluence was found to be consistent with the value reported from nuclear-reactor-based BNCT experiments. The induced activity of each nuclide can be estimated by entering the saturated activity of each nuclide, sample mass, irradiation time, and proton current into the derived activation equation in our accelerator-based BNCT system.

【 授权许可】

Unknown