Indications and pitfalls of immunohistochemistry in head and neck cancer

Revista Brasileira de Otorrinolaringologia

Caly, Décio de Natale¹  Viana, Acklei²  Rapoport, Abrão³ 

[1] Hospital Heliópolis, São Paulo;Universidade de São Paulo;Universidade de São Paulo, São Paulo

关键词: carcinoma;    squamous cell;    head and neck neoplasms;    immunohistochemistry;    lymphoma;    sarcoma.;   

DOI  :  10.5935/1808-8694.20130013

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. OBJECTIVE: To assess the use of IHC in cases of head and neck tumor. METHOD: This is a retrospective study of the cases included in the Cancer Registry of the institution. RESULTS: IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36%), CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%). CONCLUSIONS: IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors.

【 授权许可】

CC BY