Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095

American Journal of Translational Research

Xuefei Hu¹ 

[1] Department of Thoracic, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China

关键词: Non-small cell lung cancer;    lncRNA;    LINC01296;    miR-5095;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Long noncoding RNAs (lncRNAs) played in authentic biological cell roles such as cell apoptosis, cycle, differentiation, development, migration and invasion. However, the expression pattern and function of a new lncRNA LINC01296 in non-small cell lung cancer (NSCLC) are unknown and need to be studied. In our study, we indicate that the expression of LINC01296 was overexpressed in NSCLC samples compared to adjacent non-tumor tissues. Ectopic expression of LINC01296 promoted NSCLC cell proliferation and migration. Moreover, we demonstrated that LINC01296 has a potential binding site for miR-5095 by using online program tool StarBase. Overexpression of LINC01296 inhibited the expression of miR-5095 in the A549 cell. Furthermore, the miR-5095 expression was downregulated in the NSCLC tissues than in the adjacent non-tumor tissues. In addition, we found that there is a negative correlation between miR-5095 expression and LINC01296 level in the NSCLC tissues. Overexpression of miR-5095 suppressed NSCLC cell proliferation and migration. Finally, we demonstrate that ectopic expression of LINC01296 promoted cell proliferation and migration via inhibiting miR-5095 expression. These results suggested that LINC01296 might act a role as an oncogene in the tumorigenesis and development of NSCLC.

【 授权许可】

CC BY-NC