A New Type of LSPR Sensor Featuring Immobilized Liposome or Phospholipid Single Layer

Proceedings

Saito, Masato¹  Kawasaki, Masahiro²  Yoshikawa, Hiroyuki³  Jiang, Shu⁴ 

[1] Author to whom correspondence should be addressed.;Electronics, Kyoto Institute of Technology, Kyoto 606-8585, Japan;Graduate School of Engineering, Osaka University, Suita 565-0871, Japan;Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018

关键词: LSPR;    biosensor;    nanostructure;    nanopillar;    phospholipid;    liposome;    high-sensitive detection;   

DOI  :  10.3390/proceedings2130791

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

We have fabricated a new type of LSPR sensor featuring immobilized liposome or phospholipid single layer. LSPR principally shows an ultrahigh sensitivity on surface dielectric environmental change due to interaction with target, but little has been reported so far on applying phospholipid membranes and/or liposomes as model cell membrane. We newly tried to investigate biosensing capabilities using the membranes of the both structures on Au nanostructures of LSPR sensor chip. As a result, it was confirmed that the phospholipid single layer is more effective to improve the sensitivity than the liposome. Finally, we have clearly detected 100 nM target protein of CAB and estimated a possible detection of 10 nM range from wavelength resolution by interaction with the phospholipid single layer.

【 授权许可】

CC BY