The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

Purinergic Signalling

Gillian E. Knight¹  Geoffrey Burnstock² 

[1] The University of Melbourne;University College Medical School

关键词: Pain;    Infection;    Cancer;    CNS disorders;    Cardiovascular;    Airways;    Diabetes;    Kidney;    Bladder;    Liver;    Gut;    Immune cells;   

DOI  :  10.1007/s11302-017-9593-0

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation channels sometimes leading to cell proliferation, whereas high concentrations of ATP open large pores that release inflammatory cytokines and can lead to apoptotic cell death. Since many diseases involve inflammation and immune responses, and the P2X7R regulates inflammation, there has been recent interest in the pathophysiological roles of P2X7R and the potential of P2X7R antagonists to treat a variety of diseases. These include neurodegenerative diseases, psychiatric disorders, epilepsy and a number of diseases of peripheral organs, including the cardiovascular, airways, kidney, liver, bladder, skin and musculoskeletal. The potential of P2X7R drugs to treat tumour progression is discussed.

【 授权许可】

CC BY