Surface Functionalization of SU-8 Vertical Waveguide for Biomedical Sensing: Bacteria Diagnosis

Proceedings

Zhang, Yongmeng¹  Otten, Linda²  French, Paddy³  Pandraud, Grégory⁴  Xin, Yu⁵ 

[1] College of Mechatronics Engineering and Automation, NUDT, Changsha 410073, China;Department of Biotechnology, TNW, TU Delft, 2629HZ Delft, The Netherlands;Electronic Instrumentation Lab, EWI, TU Delft, 2628CD Delft, The Netherlands;Else Kooi Laboratory, TU Delft, 2628CT Delft, The Netherlands;State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China

关键词: SU-8;    vertical waveguide;    biomedical sensing;    surface functionalization;   

DOI  :  10.3390/proceedings2131081

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

In this paper, we present an SU-8 based evanescent waveguide with a vertical structure as a biomedical sensor. The waveguide is designed vertically to generate evanescent waves on both left and right surfaces for sensing. It is fabricated by E-beam lithography with only one-step process which has the advantage of a better surface quality compared with commonly used dry etching methods. Furthermore, fabrication time and cost is cut down greatly. The surface of the designed waveguide can be functionalized with antibodies to immobilize specific bacteria on it. After surface functionalization and incubation with E. coli solutions of different concentrations, the waveguides absorption was measured. The results demonstrate that the waveguide is sensitive to E. coli concentration changes. In addition, tapers were designed and added to the waveguide to relieve the alignment tolerance for the aim of making a plug-and-play bedside diagnostic system.

【 授权许可】

CC BY