Enantioselective Organocatalytic Mannich Reaction and Fluorination Sequence of Pyrazolones to Isatin‐derived Ketimines

Bulletin of the Korean Chemical Society

Hye Im Jung¹ 

[1] Department of Chemistry Soonchunhyang University Chungnam South Korea

关键词: Oxindole‐;    pyrazolone adducts;    Bifunctional organocatalyst;    Ketimines;    Pyrazolones;   

DOI  :  10.1002/bkcs.11625

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An efficient asymmetric synthesis of oxindole‐pyrazolone adducts via organocatalytic Mannich reaction of 1‐phenyl‐1H‐pyrazol‐5(4H)‐ones with ketimine derivatives derived from isatins, followed by sequential electrophilic fluorination, has been developed. This approach offers a facile way to prepare chiral 3‐amino‐3‐(4‐fluoropyrazol‐4‐yl)‐substituted oxindole derivatives with a wide range of functional group tolerance.

【 授权许可】

Unknown