Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers

Proceedings

Rocchiccioli, Silvia¹  Meucci, Sandro²  Tsopela, Aliki³  Pelosi, Gualtiero⁴ 

[1] Author to whom correspondence should be addressed.;Institute of Clinical Physiology CNR, 56124 Pisa, Italy;Micronit Microtechnologies BV, 7511 AH Enschede, The Netherlands;Presented at the 18th International Conference on Experimental Mechanics, Brussels, Belgium, 1–5 July 2018

关键词: Lab-on-Chip;    polymer-based microfluidics;    cardiac biomarkers;   

DOI  :  10.3390/ICEM18-05215

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

We report an easy-to-use Lab-on-Chip (LoC) device able to detect soluble, circulating biomarkers in plasma that are relevant to Coronary Artery Disease (CAD). The LoC prototype is developed within the SMARTool European project and is intended to be used for Point-of-Care (PoC) testing of patients with CAD, facilitating more rapid and efficient monitoring and treatment decisions. A LoC prototype is presented, enabling chemiluminescent assays to be performed on chip targeting biomarkers relevant to CAD. In parallel, a robust technology for electrostatically actuated, capillary burst valve for PoC applications, integrated in potentially disposable, thermoplastic devices is reported. The devices were fabricated using easily scalable fabrication techniques and can be used to perform multistep assays on single-use microfluidic devices.

【 授权许可】

CC BY