Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice

The journal of physiological sciences: JPS

Hironobu Morita¹  Naoyuki Kawao²  Kazuaki Nishida³ 

[1] Gifu University Graduate School of Medicine;Kindai University Faculty of Medicine;Mouse Epigenetics Project, ISS/Kibo Experiment, Japan Aerospace Exploration Agency

关键词: Gravity change;    Muscle;    Bone;    Vestibular system;   

DOI  :  10.1007/s12576-017-0566-4

学科分类：生理学

来源: Springer

【 摘 要 】

We recently reported that hypergravity with 3 g for 4 weeks affects muscle and bone through the vestibular system in mice. The purpose of this study was to investigate the effects of hypergravity with 2 g, which had no influence on circulating glucocorticoid level, on the gene levels in muscle and bone, as well as the roles of the vestibular system in those changes using vestibular lesioned (VL) mice. Hypergravity for 2 and 8 weeks or VL exerted little effects on the mRNA levels of muscle differentiation factors and myokines in the soleus muscle. Although hypergravity for 2 weeks significantly elevated alkaline phosphatase (ALP) and type I collagen mRNA levels in the tibia, VL significantly attenuated the levels of ALP mRNA enhanced by hypergravity. In conclusion, the present study suggests that a 2-g load for 2 weeks enhances osteoblast differentiation partly through the vestibular system in mice.

【 授权许可】

CC BY