期刊论文详细信息
Journal of Biological Research
Changes in the microstructure of compact and trabecular bone tissues of mice subchronically exposed to alcohol
Monika Martiniakova1  Anna Sarocka2  Ramona Babosova3 
[1] Constantine the Philosopher University in Nitra;Georg-August University;Pedagogical University of Cracow
关键词: Alcohol;    Microstructure;    Compact bone;    Trabecular bone;    Mice;   
DOI  :  10.1186/s40709-018-0079-1
学科分类:生物科学(综合)
来源: Springer
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【 摘 要 】

BackgroundAlcohol is one of the most commonly consumed neurotoxins by humans. Its negative effect on bone health is known for a long time. However, its impact on qualitative and quantitative 2D characteristics of the compact bone is still unclear. Therefore, the aim of this study was to investigate in detail the effects of subchronic alcohol exposure on compact and trabecular bone tissues microstructure of laboratory mice using 2D and 3D imaging methods. Ten clinically healthy 12 weeks-old mice (males) were randomly divided into two groups. Animals from experimental group (group E; n = 5) drank a solution composed of 15% ethanol and water (1.7 g 100% ethanol kg−1 b.w. per day) for 8 weeks, while those from control group (group C; n = 5) drank only water.

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