A systematic review of diffusion weighted MRI studies of white matter microstructure in adolescent substance users

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:37

Review

Baker, Simon T. E.^1,2,3,4,5,6  Yuecel, Murat^3,4,5,6  Fornito, Alex^3,4,5,6  Allen, Nicholas B.⁷  Lubman, Dan I.^1,2 

[1] Monash Univ, Eastern Hlth Clin Sch, Turning Point Alcohol & Drug Ctr, Clayton, Vic 3800, Australia

[2] Eastern Hlth, Melbourne, Vic, Australia

[3] Monash Univ, Sch Psychol & Psychiat, Monash Clin & Imaging Neurosci, Clayton, Vic 3800, Australia

[4] Monash Univ, Monash Biomed Imaging, Clayton, Vic 3800, Australia

[5] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic 3010, Australia

[6] Melbourne Hlth, Melbourne, Vic, Australia

[7] Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic 3010, Australia

关键词: Adolescent;    Alcohol;    Brain;    Cannabis;    Development;    Diffusion tensor imaging;    Diffusion weighted MRI;    Microstructure;    Neuroimaging;    Substance abuse;    Substance use disorders;    White matter;   

DOI  :  10.1016/j.neubiorev.2013.06.015

来源: Elsevier

【 摘 要 】

Recent studies using diffusion weighted magnetic resonance imaging (DW-MRI) have provided evidence of abnormal white matter microstructure in adults with substance use disorders (SUDs). While there is a growing body of research using DW-MRI to examine the impact of heavy substance use during adolescence, this literature has not been systematically reviewed. Online databases were searched for DW-MRI studies of adolescent substance users, and 10 studies fulfilled the inclusion and exclusion criteria. We identified consistent evidence for abnormal white matter microstructure in neocortical association pathways as well as in projection and thalamic pathways. Dose-dependent relationships between DW-MRI measures and patterns of substance use were also observed. The consistency of these findings with DW-MRI research in adults suggests that white matter microstructure is impacted in the early stages of heavy substance use. However, given the largely cross-sectional nature of the available data, important questions remain regarding the extent to which white matter abnormalities are a consequence of adolescent exposure to alcohol and other drugs of abuse or reflect pre-existing differences that increase risk for SUDs. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free