Applications of recombinant Pichia pastoris in the healthcare industry

Revista de microbiologia

Weinacker, Daniel¹  Rabert, Claudia² 

[1] Universidad de La Frontera, Temuco, Chile;Universidade de São Paulo, São Paulo, Brazil

关键词: yeast;    heterologous expression system;    recombinant protein;    production;    scale up.;   

DOI  :  10.1590/S1517-83822013000400004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Microbiologia / Brazilian Society for Microbiology

【 摘 要 】

Since the 1970s, the establishment and development of the biotech industry has improved exponentially, allowing the commercial production of biopharmaceutical proteins. Nowadays, new recombinant protein production is considered a multibillion-dollar market, in which about 25% of commercial pharmaceuticals are biopharmaceuticals. But to achieve a competitive production process is not an easy task. Any production process has to be highly productive, efficient and economic. Despite that the perfect host is still not discovered, several research groups have chosen Pichia pastoris as expression system for the production of their protein because of its many features. The attempt of this review is to embrace several research lines that have adopted Pichia pastoris as their expression system to produce a protein on an industrial scale in the health care industry.

【 授权许可】

CC BY-NC