The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma

The Journal of Veterinary Medical Science

Hajime ASADA¹  Hirotaka TOMIYASU²  Osamu ICHII³ 

[1] Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;Laboratory of Anatomy, Department of Basic Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan

关键词: histiocytic sarcoma;    intratumor heterogeneity;    mutation;    TP53 gene;   

DOI  :  10.1292/jvms.18-0419

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The mutations of TP53 gene are frequently observed in canine histiocytic sarcoma (HS). The objective of this study was to examine the distribution of tumor cells with TP53 gene mutations. Tumor tissues were divided into three or four regions and TP53 gene mutations were examined. TP53 gene mutations were detected only in parts of the HS tissues from six of the eight dogs, and the frequency of the mutant allele varied (0–65%) among the tumor regions. This study suggests that canine HS can exhibit intratumor heterogeneity. Further studies are needed to examine the clinical significance of the intratumor heterogeneity of TP53 gene mutations.

【 授权许可】

Unknown